The Regional Network on HIV/AIDS, Rural Livelihoods and Food Security (RENEWAL) was launched in 2001. Facilitated by the International Food Policy Research Institute (IFPRI) and with support from several donors, RENEWAL is a growing regional network-of-networks. Currently active in Malawi, Uganda, Zambia, South Africa and Kenya, RENEWAL comprises national networks of food and nutrition-relevant organizations (public, private and non-governmental) together with partners in AIDS and public health. RENEWAL aims to enhance understanding of the worsening interactions between HIV/AIDS and food and nutrition security, and to facilitate a comprehensive response to these interactions. The core pillars are locally prioritized action research, capacity strengthening and policy communications. RENEWAL believes that the process of developing networks is both a means and an end. Impact may be enhanced and sustained when locally prioritised research is linked with capacity strengthening and policy communications.